96th DOG Annual Meeting, 1998



A. Kersten, C. Althaus, R. Sundmacher

Introduction: Microsporidia are spore-forming, obligate intracellular

protozoa. Only few reports of ocular infections are published. Microsporidial keratoconjunctivitis in immunodeficient patients has a characteristic appearance.

Case report: A 34 year old woman with AIDS complained of bilateral blurred vision. She had a mild conjunctivitis and disseminate, not very prominent intraepithelial corneal opacities. Within 6 months the visual acuity decreased to 0,05 because of inefficiency of propamidine isethionate eye drops, kanamycin and artificial tears. A renewed conjunctival smear was positive for microsporidia. Fumagillin eye drops 0,07 mg/ml 7 times daily were given. Within 2 weeks an impressive improvement was seen. Because of an persisting diarrhea 400 mg Albendazol twice daily was added orally without success.

Discussion: The biomicroscopically changes of microsporidial

keratoconjunctivitis are characteristic and lead to the clinical diagnosis. Fumagillin is in vitro and clinically a potent antimicrosporidial agent with an extremely broad therapeutic range.

Eye Hospital, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf