EXPERIMENTAL IMPLANTATION AND FIXATION OF POLY- DIMETHYLSILOXANE SHEKTS AS A MODKL OF SURFACE- MODIFIED RETINAL MICROCHIPS
C.E. Uhlig1, U. Thelen1, H.Ch. Lüdtke-Handjery2, H. Richter2, N. Völker2, H. Gerding1
Introduction: Polydimethylsiloxane implants with artificially induced microperforations were manufactured for an in vivo test of putative intraocular implantation as a coating material of retina stimulators. Polydimethylsiloxane is a rather transparent and elastic material, thus far capable of beeing smoothly attached to tissue. Its adhesive capacities can be optimized by surface modification with plasma etching and copolymerisation of the surface.
Material and methods: Investigations were performed using pigmented rabbits following preoperative cryofixation. Plasmin assisted vitrectomy was done prior to the implantation of the surface activated structure.
Results: Implantation of the devices was possible without retinal injuries. No pucker, proliferative vitreoretinopathy or significant clinical proliferations occured following to the tight tissue-surface-fixation of the implant. The localization revealed funduscopically stable after 3 months.
Conclusions: Polydimethylsiloxane proved a useful biocompatibility even after long-term implantation. Its adhesive effciency following surface modification is yet to be investigated. The artificially induced microperforations probably enable the implant to get additionally fixation to the retina by cell-migration into the perforation holes.
Sponsored by BMB+F (KZ: 01 IN 501 D) Cooperation within the EPI-RET- consortium
1Dept. of Ophthalmology, Univ. Münster, D-48129 Münster
2Dept. Of Pathology, RWTH Aachen, D-52057 Aachen